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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
LMNA
All Species:
26.97
Human Site:
T496
Identified Species:
53.94
UniProt:
P02545
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P02545
NP_005563.1
664
74139
T496
L
K
A
G
Q
V
V
T
I
W
A
A
G
A
G
Chimpanzee
Pan troglodytes
NP_001092024
664
74135
T496
L
K
A
G
Q
V
V
T
I
W
A
A
G
A
G
Rhesus Macaque
Macaca mulatta
XP_001113604
726
80498
T558
L
K
A
G
Q
V
V
T
I
W
A
A
G
A
G
Dog
Lupus familis
XP_864434
665
74207
T497
L
K
A
G
Q
V
V
T
I
W
A
A
G
A
G
Cat
Felis silvestris
Mouse
Mus musculus
P48678
665
74219
T496
L
K
A
G
Q
V
V
T
I
W
A
S
G
A
G
Rat
Rattus norvegicus
P48679
665
74305
T496
L
K
A
G
Q
V
V
T
I
W
A
S
G
A
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516432
873
92759
I567
G
A
L
W
I
L
V
I
L
V
Y
G
E
I
L
Chicken
Gallus gallus
P13648
657
73146
K491
F
P
P
K
F
T
L
K
A
G
Q
A
V
T
I
Frog
Xenopus laevis
P11048
665
74901
T493
L
K
A
G
Q
T
V
T
I
W
A
S
G
A
G
Zebra Danio
Brachydanio rerio
NP_694503
659
73714
R489
L
G
H
W
Q
V
K
R
Q
I
G
S
G
T
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P08928
622
71282
V460
D
E
S
E
D
H
S
V
A
D
Y
Y
V
S
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q21443
566
64066
F404
T
S
V
H
H
V
S
F
S
S
G
G
A
S
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
90.5
98
N.A.
96.5
97.1
N.A.
47.4
78.6
73.3
66.7
N.A.
35
N.A.
27.5
N.A.
Protein Similarity:
100
99.8
90.9
99.2
N.A.
98.9
98.9
N.A.
54.9
86.7
86.1
81.6
N.A.
57.9
N.A.
43.8
N.A.
P-Site Identity:
100
100
100
100
N.A.
93.3
93.3
N.A.
6.6
6.6
86.6
26.6
N.A.
0
N.A.
6.6
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
20
13.3
93.3
33.3
N.A.
20
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
59
0
0
0
0
0
17
0
59
42
9
59
17
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
0
0
0
9
0
0
0
0
9
0
0
0
0
0
% D
% Glu:
0
9
0
9
0
0
0
0
0
0
0
0
9
0
0
% E
% Phe:
9
0
0
0
9
0
0
9
0
0
0
0
0
0
0
% F
% Gly:
9
9
0
59
0
0
0
0
0
9
17
17
67
0
59
% G
% His:
0
0
9
9
9
9
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
9
0
0
9
59
9
0
0
0
9
9
% I
% Lys:
0
59
0
9
0
0
9
9
0
0
0
0
0
0
0
% K
% Leu:
67
0
9
0
0
9
9
0
9
0
0
0
0
0
9
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
9
9
0
0
0
0
0
0
0
0
0
0
0
9
% P
% Gln:
0
0
0
0
67
0
0
0
9
0
9
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% R
% Ser:
0
9
9
0
0
0
17
0
9
9
0
34
0
17
0
% S
% Thr:
9
0
0
0
0
17
0
59
0
0
0
0
0
17
0
% T
% Val:
0
0
9
0
0
67
67
9
0
9
0
0
17
0
0
% V
% Trp:
0
0
0
17
0
0
0
0
0
59
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
17
9
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _